Detection of presymptomatic Parkinson's disease: Combining smell tests, transcranial sonography, and SPECT
Identifieur interne : 003D51 ( Main/Exploration ); précédent : 003D50; suivant : 003D52Detection of presymptomatic Parkinson's disease: Combining smell tests, transcranial sonography, and SPECT
Auteurs : Ulrike Sommer [Allemagne] ; Thomas Hummel [Allemagne] ; Katja Cormann [Allemagne] ; Antje Mueller [Allemagne] ; Johannes Frasnelli [Allemagne] ; Joachim Kropp [Allemagne] ; Heinz Reichmann [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2004-10.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Echoencephalography (methods), Female, Humans, Iodine Radioisotopes (diagnostic use), Male, Medical screening, Middle Aged, Nervous system diseases, Olfaction Disorders (diagnosis), Olfaction Disorders (etiology), Parkinson Disease (complications), Parkinson Disease (diagnosis), Parkinson disease, Photon, Predictive Value of Tests, Prospective Studies, Radiopharmaceuticals (diagnostic use), Severity of Illness Index, Single photon emission tomography, Sonography, Tomography, Emission-Computed, Single-Photon, Tropanes (diagnostic use), neurodegeneration, olfaction, predictor, smell, transcranial sonography.
- MESH :
- chemical , diagnostic use : Iodine Radioisotopes, Radiopharmaceuticals, Tropanes.
- complications : Parkinson Disease.
- diagnosis : Olfaction Disorders, Parkinson Disease.
- etiology : Olfaction Disorders.
- methods : Echoencephalography.
- Adult, Aged, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Severity of Illness Index, Tomography, Emission-Computed, Single-Photon.
Abstract
Olfactory loss is among the early signs of Parkinson's disease (PD). We investigated whether “idiopathic” olfactory dysfunction might relate to signs of nigral degeneration. Olfactory tests were combined with transcranial sonography of the substantia nigra and single photon emission computed tomography (SPECT) imaging. Thirty patients diagnosed with idiopathic olfactory loss participated. Eleven of these patients exhibited an increased echogenicity of the SN in the transcranial sonography. In 10 of these 11 patients, SPECT scans with 123I‐FP‐CIT were performed. Median uptake ratios in the basal ganglia were pathological in 5 patients, 2 patients exhibited borderline findings, and 3 patients had normal results. Considering patients with idiopathic olfactory dysfunction, noninvasive transcranial sonography seems to be helpful in identifying patients potentially at risk to develop PD. Longitudinal follow‐up studies are necessary to estimate the ratio of patients with dopaminergic cell loss in the basal ganglia who will develop PD in the future. © 2004 Movement Disorder Society
Url:
DOI: 10.1002/mds.20141
Affiliations:
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We investigated whether “idiopathic” olfactory dysfunction might relate to signs of nigral degeneration. Olfactory tests were combined with transcranial sonography of the substantia nigra and single photon emission computed tomography (SPECT) imaging. Thirty patients diagnosed with idiopathic olfactory loss participated. Eleven of these patients exhibited an increased echogenicity of the SN in the transcranial sonography. In 10 of these 11 patients, SPECT scans with 123I‐FP‐CIT were performed. Median uptake ratios in the basal ganglia were pathological in 5 patients, 2 patients exhibited borderline findings, and 3 patients had normal results. Considering patients with idiopathic olfactory dysfunction, noninvasive transcranial sonography seems to be helpful in identifying patients potentially at risk to develop PD. Longitudinal follow‐up studies are necessary to estimate the ratio of patients with dopaminergic cell loss in the basal ganglia who will develop PD in the future. © 2004 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Dresde</li><li>Saxe (Land)</li></region><settlement><li>Dresde</li></settlement></list><tree><country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Sommer, Ulrike" sort="Sommer, Ulrike" uniqKey="Sommer U" first="Ulrike" last="Sommer">Ulrike Sommer</name></region><name sortKey="Cormann, Katja" sort="Cormann, Katja" uniqKey="Cormann K" first="Katja" last="Cormann">Katja Cormann</name><name sortKey="Frasnelli, Johannes" sort="Frasnelli, Johannes" uniqKey="Frasnelli J" first="Johannes" last="Frasnelli">Johannes Frasnelli</name><name sortKey="Hummel, Thomas" sort="Hummel, Thomas" uniqKey="Hummel T" first="Thomas" last="Hummel">Thomas Hummel</name><name sortKey="Kropp, Joachim" sort="Kropp, Joachim" uniqKey="Kropp J" first="Joachim" last="Kropp">Joachim Kropp</name><name sortKey="Mueller, Antje" sort="Mueller, Antje" uniqKey="Mueller A" first="Antje" last="Mueller">Antje Mueller</name><name sortKey="Reichmann, Heinz" sort="Reichmann, Heinz" uniqKey="Reichmann H" first="Heinz" last="Reichmann">Heinz Reichmann</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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